Does epidermal thickening explain GJB2 high carrier frequency and heterozygote advantage?
نویسندگان
چکیده
منابع مشابه
Heterozygote Advantage for Fecundity
Heterozygote advantage, or overdominance, remains a popular and persuasive explanation for the maintenance of genetic variation in natural populations in the face of selection. However, despite being first proposed more than 80 years ago, there remain few examples that fit the criteria for heterozygote advantage, all of which are associated with disease resistance and are maintained only in the...
متن کاملFurther evidence for heterozygote advantage of GJB2 deafness mutations: a link with cell survival.
G ap junctions composed of connexins (Cx) are intercellular channels that provide a mechanism of synchronised cellular response facilitating the metabolic and electronic functions of the cell. At least 20 human Cx genes have been described, many of which harbour germline mutations that are associated with a variety of human diseases. Recessive mutations in the coding region of GJB2 encoding Cx2...
متن کاملLETTER TO JMG Further evidence for heterozygote advantage of GJB2 deafness mutations: a link with cell survival
G ap junctions composed of connexins (Cx) are intercellular channels that provide a mechanism of synchronised cellular response facilitating the metabolic and electronic functions of the cell. At least 20 human Cx genes have been described, many of which harbour germline mutations that are associated with a variety of human diseases. Recessive mutations in the coding region of GJB2 encoding Cx2...
متن کاملDoes Comparative Advantage Explain Export Patterns in China?
Revealed comparative advantage indices are calculated for China (1980-2000 period) and the Chinese provinces (1990-1998 period) and then incorporated into a reduced form export equation. The results of China’s export patterns show that China has moved from a heavy industry-oriented development strategy to a comparative advantage one, with, however, marked differences among provinces. The econom...
متن کاملDoes cultural integration explain a mental health advantage for adolescents?
BACKGROUND A mental health advantage has been observed among adolescents in urban areas. This prospective study tests whether cultural integration measured by cross-cultural friendships explains a mental health advantage for adolescents. METHODS A prospective cohort of adolescents was recruited from 51 secondary schools in 10 London boroughs. Cultural identity was assessed by friendship choic...
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ژورنال
عنوان ژورنال: European Journal of Human Genetics
سال: 2008
ISSN: 1018-4813,1476-5438
DOI: 10.1038/ejhg.2008.225